HomeMedicationsTrazodone (Desyrel)
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Prescribed to dogs: use only as directed

Vets prescribe this for dogs, so being on it is not a problem in itself. This page is about what happens when a dog gets more than it was meant to have.

DogSafe severity score
4/10

Trazodone is used by veterinarians for selected anxiety and behavior-related situations. It affects serotonin, and interactions with other serotonin-active medicines can be important.

Educational reference. Not individualized veterinary advice.(more)

See this page's cited references for supporting information and our Sources page for the reference organizations we use. Citations do not imply that those organizations reviewed or endorsed DogSafe.

Part of Antidepressants and anxiety medication on our medication safety hub.

Got the amount wrong, or your dog reached the container?

Call the practice that prescribed it: they know the dose your dog is on, which is what decides whether this matters. Out of hours, either line below is open.

Exposure details to have ready

These are the questions a veterinarian or poison-control operator will ask. Fill in what you know and leave the rest blank. This tool does not estimate a dose or a risk score: medication risk depends on the exact ingredient, strength, and formulation, so the assessment has to come from the clinician on the call.

Signs so far
Before you call
  • Keep the package, blister pack, or prescription bottle. The strength and the full ingredient list are what make the advice specific.
  • Do not induce vomiting unless a veterinarian or poison-control professional tells you to. It is the wrong move for several medications and can cause harm on its own.
  • Do not give milk, food, salt, hydrogen peroxide, or any home remedy on your own.
  • Do not give a second dose of anything to make up for one you think was missed.
  • Count what is left in the packet, so the number missing can be worked out.

Your exposure summary

Read this down the phone or paste it into a message to your vet. It stays on your device; nothing here is sent to DogSafe.

Why Trazodone (Desyrel) needs caution

Trazodone is used by veterinarians for selected anxiety and behavior-related situations. It affects serotonin, and interactions with other serotonin-active medicines can be important. Sleepiness, poor coordination and digestive effects can occur; a dog can also become more anxious. Provide the complete medication list after an accidental extra dose. Do not add or repeat a dose because the expected calming effect has not appeared.

Part of the Xanax (Alprazolam) guide

For related dog-safety questions and product-by-product answers, see the complete xanax (alprazolam) guide.

Signs to watch for

Sedation, poor coordination, vomiting or increased anxiety. Severe reactions can involve overheating, seizures or breathing difficulty.

Related items

Check the exact item or ingredient before assuming two similar exposures carry the same risk.

What to do next

Have the exact ingredient name, strength or concentration, amount missing, possible time, dog’s weight and current medications ready. Report chewed packaging and ask what to do before the next prescribed dose.

🚨Step-by-step: what to do in the first 10 minutes →
Animal poison control

FAQ

How much Trazodone (Desyrel) is dangerous?

This page gives no dose or safe-exposure threshold. Follow the prescription for this dog; ask the veterinarian to confirm the product and any change to the schedule.

Can I treat this at home?

Prevent further access and keep the packaging. Do not induce vomiting or give a home remedy unless a veterinary professional directs you for this exposure.

When should I call the vet?

Call promptly after an accidental ingestion, suspected extra dose, unknown amount or unexpected reaction. Breathing difficulty, collapse, seizures or inability to respond needs emergency veterinary care. Do not wait for those signs before calling.

Why does the vet need the other medications?

Trazodone can interact with other medicines, including some antidepressants and tramadol. List prescriptions, supplements and recent doses so the veterinarian can assess the combination rather than trazodone alone.

SourcesUpdated September 12, 2026
  • VCA Animal Hospitals: trazodone
  • Pet Poison Helpline: what to remember during a poisoning
Read DogSafe's sources and review policy →
Compiled from veterinary poison-control and medical reference sources, including the ASPCA Animal Poison Control Center, the Pet Poison Helpline, and the Merck Veterinary Manual. This is general educational information, not a diagnosis or a substitute for examination by your veterinarian. DogSafe's severity ratings are general editorial hazard ratings, not a calculation of your dog's exposure. They cannot establish that an amount is safe. In an emergency, call ASPCA Animal Poison Control at 888-426-4435 or the Pet Poison Helpline at 855-764-7661.