Also sold as Zoloft, Lustral
At amounts a dog can reach in a normal household, this needs a vet or poison-control call straight away rather than watching and waiting.
Sertraline is one of the most commonly prescribed antidepressants, which makes it one of the most commonly swallowed by dogs. Too much serotonin causes agitation, tremors, a racing heart and a rising body temperature. Call before signs appear rather than after.
Call a vet or poison control now. Do not wait for symptoms.
ASPCA Animal Poison Control (888) 426-4435 or Pet Poison Helpline (855) 764-7661. A consultation fee may apply.
Source-backed guidance. Not individualized veterinary advice.(more)
Compiled from veterinary poison-control and medical references, including the ASPCA Animal Poison Control Center, Pet Poison Helpline, and Merck Veterinary Manual.
Part of Antidepressants and anxiety medication on our medication safety hub.
Part of our guide to Dog Ate Antidepressants, Stimulants or Sleep Medication.
Do not wait for symptoms and do not wait until you have filled in the form below. Call first, then use the checklist while you are on the phone.
Available 24/7. A consultation fee may apply.
Exposure details to have ready
These are the questions a veterinarian or poison-control operator will ask. Fill in what you know and leave the rest blank. This tool does not estimate a dose or a risk score: medication risk depends on the exact ingredient, strength, and formulation, so the assessment has to come from the clinician on the call.
- Keep the package, blister pack, or prescription bottle. The strength and the full ingredient list are what make the advice specific.
- Do not induce vomiting unless a veterinarian or poison-control professional tells you to. It is the wrong move for several medications and can cause harm on its own.
- Do not give milk, food, salt, hydrogen peroxide, or any home remedy on your own.
- Do not give a second dose of anything to make up for one you think was missed.
- Count what is left in the packet, so the number missing can be worked out.
Your exposure summary
Read this down the phone or paste it into a message to your vet. It stays on your device; nothing here is sent to DogSafe.
Why Sertraline (Zoloft) is dangerous
Sertraline is an SSRI: it raises serotonin by blocking its reuptake. A dog that swallows a human dose can develop serotonin syndrome, in which agitation, dilated pupils, tremors, vomiting, a fast heart rate and hyperthermia build together. Some dogs go the other way and become unusually sedated instead, which owners misread as the exposure being mild. Body temperature is the part that causes lasting harm, so it is worth saying on the call whether your dog feels hot and is panting hard.
Part of the Antidepressants guide
For related dog-safety questions and product-by-product answers, see the complete antidepressants guide.
Signs to watch for
Signs may be delayed. Depending on the drug: bruising, pale gums, blood in urine or stool, weakness, collapse, tremors, seizures, or changes in breathing or heart rhythm
Related items
Check the exact item or ingredient before assuming two similar exposures carry the same risk.
What to do next
Call first. Then find the packet, count what is left, note the strength and the time, and keep the container to hand for the call.
🚨Step-by-step: what to do in the first 10 minutes →Available 24/7. A consultation fee may apply.
A closer look at sertraline (zoloft)
Sertraline is an SSRI: it raises serotonin by blocking its reuptake. A dog that swallows a human dose can develop serotonin syndrome, in which agitation, dilated pupils, tremors, vomiting, a fast heart rate and hyperthermia build together. Some dogs go the other way and become unusually sedated instead, which owners misread as the exposure being mild. Body temperature is the part that causes lasting harm, so it is worth saying on the call whether your dog feels hot and is panting hard. The details below use the specific facts for this exposure, rather than treating it like every other medication question.
1. Start with the exact exposure
For a closely related comparison, read Antidepressants. Do not look for a threshold here. This is a drug where a plausible household exposure is treated as urgent regardless of the number of tablets, and where the delay before signs appear is part of the hazard rather than a reassurance.
2. Use the facts to decide whether to monitor or call
Another helpful reference is Bupropion (Wellbutrin). There is nothing to manage at home. Call a vet or an animal poison-control line now, before symptoms, and do not induce vomiting unless they instruct you to. Immediately, whether or not your dog seems unwell. A normal-looking dog in the first hours is not evidence that the exposure was small.
3. If the details are uncertain
Follow the first 10 minutes guide. Call first. Then find the packet, count what is left, note the strength and the time, and keep the container to hand for the call.
FAQ
Do not look for a threshold here. This is a drug where a plausible household exposure is treated as urgent regardless of the number of tablets, and where the delay before signs appear is part of the hazard rather than a reassurance.
There is nothing to manage at home. Call a vet or an animal poison-control line now, before symptoms, and do not induce vomiting unless they instruct you to.
Immediately, whether or not your dog seems unwell. A normal-looking dog in the first hours is not evidence that the exposure was small.
Vets do prescribe SSRIs for canine anxiety and compulsive behavior, though fluoxetine and clomipramine are the more usual choices. That does not make a human bottle safe: the strength is different and the dose was calculated for a person.
- Merck Veterinary Manual — toxicoses in animals from human antidepressants, anxiolytics and sleep aids
- ASPCA Animal Poison Control Center — human medications
- Pet Poison Helpline — top 10 human medications poisonous to pets
- Merck Veterinary Manual: Toxicoses from human antidepressants, anxiolytics and sleep aids
- ASPCA Animal Poison Control
- Pet Poison Helpline: Top 10 human medications poisonous to pets