HomeMedicationsMetformin (Glucophage)
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Human formulation: not for unsupervised use

The human product is the problem: the strength, the coating, or an added ingredient makes it wrong for a dog even when the active ingredient is familiar.

DogSafe severity score
4/10

Metformin products include plain tablets, extended-release tablets, liquids and combinations with other diabetes drugs. These are not interchangeable exposures.

Educational reference. Not individualized veterinary advice.(more)

See this page's cited references for supporting information and our Sources page for the reference organizations we use. Citations do not imply that those organizations reviewed or endorsed DogSafe.

Part of Diabetes, hormones and vitamins on our medication safety hub.

If your dog ate Metformin (Glucophage), call now

Do not wait for symptoms and do not wait until you have filled in the form below. Call first, then use the checklist while you are on the phone.

Exposure details to have ready

These are the questions a veterinarian or poison-control operator will ask. Fill in what you know and leave the rest blank. This tool does not estimate a dose or a risk score: medication risk depends on the exact ingredient, strength, and formulation, so the assessment has to come from the clinician on the call.

Signs so far
Before you call
  • Keep the package, blister pack, or prescription bottle. The strength and the full ingredient list are what make the advice specific.
  • Do not induce vomiting unless a veterinarian or poison-control professional tells you to. It is the wrong move for several medications and can cause harm on its own.
  • Do not give milk, food, salt, hydrogen peroxide, or any home remedy on your own.
  • Do not give a second dose of anything to make up for one you think was missed.
  • Count what is left in the packet, so the number missing can be worked out.

Your exposure summary

Read this down the phone or paste it into a message to your vet. It stays on your device; nothing here is sent to DogSafe.

Why Metformin (Glucophage) needs caution

Metformin products include plain tablets, extended-release tablets, liquids and combinations with other diabetes drugs. These are not interchangeable exposures. Digestive upset can occur, and a published canine case documents severe low blood sugar and lactic acidosis after metformin ingestion. That report does not establish a safe threshold or predict the outcome for another dog. Read every active ingredient to the veterinarian and report the actual formulation rather than describing it only as a diabetes pill.

Part of the Glipizide (Glucotrol) guide

For related dog-safety questions and product-by-product answers, see the complete glipizide (glucotrol) guide.

Signs to watch for

Vomiting, diarrhea, reduced appetite, lethargy or unsteadiness; collapse or seizures requires emergency care.

Related items

Check the exact item or ingredient before assuming two similar exposures carry the same risk.

What to do next

Have the exact ingredient name, strength or concentration, amount missing, possible time, dog’s weight and current medications ready. Report chewed packaging and ask what to do before the next prescribed dose.

🚨Step-by-step: what to do in the first 10 minutes →
Animal poison control

FAQ

How much Metformin (Glucophage) is dangerous?

This page gives no dose or safe-exposure threshold. Follow the prescription for this dog; ask the veterinarian to confirm the product and any change to the schedule.

Can I treat this at home?

Prevent further access and keep the packaging. Do not induce vomiting or give a home remedy unless a veterinary professional directs you for this exposure.

When should I call the vet?

Call promptly after an accidental ingestion, suspected extra dose, unknown amount or unexpected reaction. Breathing difficulty, collapse, seizures or inability to respond needs emergency veterinary care. Do not wait for those signs before calling.

Does metformin’s different mechanism make an ingestion safe?

No. Its mechanism alone cannot establish the outcome. Report the amount and exact product, including any additional diabetes drug; serious effects have been reported after canine exposure.

SourcesUpdated September 12, 2026
  • VCA Animal Hospitals: metformin
  • Canine metformin exposure case report
Read DogSafe's sources and review policy →
Compiled from veterinary poison-control and medical reference sources, including the ASPCA Animal Poison Control Center, the Pet Poison Helpline, and the Merck Veterinary Manual. This is general educational information, not a diagnosis or a substitute for examination by your veterinarian. DogSafe's severity ratings are general editorial hazard ratings, not a calculation of your dog's exposure. They cannot establish that an amount is safe. In an emergency, call ASPCA Animal Poison Control at 888-426-4435 or the Pet Poison Helpline at 855-764-7661.