HomeMedicationsMethotrexate
💊
Toxic: keep away from dogs

Can Dogs HaveMethotrexate?

DogSafe severity score
9/10
⚕️This page is pending review by a licensed veterinarian.
Check Methotrexate for your dog

Enter your dog's details for a straight answer sized to them.

Why Methotrexate is dangerous

Methotrexate interferes with folate-dependent cell growth. Overdose can injure the gastrointestinal tract, bone marrow, liver, and kidneys, and some effects may be delayed.

Signs to watch for

Vomiting, diarrhea, mouth sores, lethargy, poor appetite, bruising or bleeding, delayed illness

What to do next

Keep the bottle or packaging, count what may be missing, and call for case-specific guidance even if your dog looks normal.

🚨Step-by-step: what to do in the first 10 minutes →
Animal poison control

FAQ

How much Methotrexate is dangerous?

Any accidental ingestion is urgent. The dosing schedule on human products can make one tablet much more consequential than expected.

Can I treat this at home?

Do not induce vomiting or give food, charcoal, or another medicine unless a veterinarian or poison specialist directs you.

When should I call the vet?

Call your veterinarian or an animal poison control center now with the product strength, amount missing, time, and your dog's weight.

Sources
  • Merck Veterinary Manual / FDA drug labeling
Compiled from veterinary poison-control and medical reference sources, including the ASPCA Animal Poison Control Center, the Pet Poison Helpline, and the Merck Veterinary Manual. This is general educational information, not a diagnosis or a substitute for examination by your veterinarian. DogSafe's severity ratings are our own assessment, calculated from published guidance and your dog's weight. In an emergency, call ASPCA Animal Poison Control at 888-426-4435 or the Pet Poison Helpline at 855-764-7661.